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Xenalon (Spironolactone)
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Spironolactone

Xenalon is a potassium-sparing diuretic that removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease. It also can be used in combination with other drugs to treat diuretic-induced low potassium (hypokalemia) and high blood pressure. Xenalon also is used to counteract the effects of excessive adrenal aldosterone production (hyperaldosteronism) that can occur from a tumor in the adrenal gland or enlarged adrenal glands (hyperplasia of the adrenal glands). Xenalon and its active metabolites are specific pharmacologic antagonists of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Xenalon causes increased amounts of sodium and water to be excreted, while potassium is retained. Xenalon acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents that act more proximally in the renal tubule.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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The preferential decoration technique was applied to label structural faults of bilayers, such as domain boundaries and other regions of molecular dislocation which are not visible by conventional morphological observations. Huge enhancement of electromechanical responses in compositionally modulated Pb(Zr(1-x )Tix)O3.

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Functional evidence suggests that the stimulation of peripheral and central opioid receptors (ORs) is able to modulate heart function. Serum levels and activity of indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase and their association with disease severity in patients with chronic kidney disease. Stereoselective syntheses and CNS activity of novel tricyclic amines.

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Occupancy of Nociceptin/Orphanin FQ Peptide Receptors by the Antagonist LY2940094 in Rats and Healthy Human Subjects. Within several days the lesion increased in size and was then falsely considered to be an intraventricular haemorrhage. Experienced nurses used the heuristic, Judging by Causal Systems (diagnostic inferences deduced from systems of causal factors) significantly more did than less-experienced nurses. A review of studies reported from 1966 to 1998 and identified through a MEDLINE search of the English-language literature on metabolic and toxic seizures and status epilepticus. Medical charts of the patients with discrepant laboratory findings were reviewed and compared with the United States Centers for Disease Control and Prevention (CDC) clinical case definition.

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Previous studies demonstrated that the number of c-Fos protein-like immunoreactive (c-Fos-IR) neurons in the medullary dorsal horn (MDH) evoked by noxious stimulation was increased after peripheral nerve injury, and such increase has been proposed to reflect the development of neuropathic pain state. The molecular mechanisms giving rise to the SBBS and GPS phenotypes are discussed.

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These results suggest that the timing of gastrulation is fixed within the cells of an embryo and cannot be altered in spite of the cell-to-cell communication that appears to exist. Molecular modeling of this inactivating TSH receptor mutation revealed potential interaction partners of R633 in transmembrane domain 3 and/or transmembrane domain 7, presumably via hydrogen bonds that could be responsible for locking the TSH receptor in a completely inactive state. This chapter describes the microtomy performed in a cryostat to produce tissue slides mounted onto glass slides suitable for MALDI.

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Interhemispheric propagation time and temporal lobe epileptogenicity. Use of a new curare simulant, My 301, in obstetrics and gynecology To study the role of the SGD sequence in FMDV receptor recognition and bovine virulence, we assembled an infectious cDNA clone of an RGD-containing A(24)Cru and derived mutant clones containing either SGD with a single nucleotide substitution in the R(144) codon or double substitutions at this position to prevent mutation of the S to an R. The size of the subunits is 7 nm and the distance between their centers is 11 nm. To estimate the association between CYP2C19 genetic variants and clinical outcomes of clopidogrel-treated patients with minor stroke or transient ischemic attack.

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Facilitated expression of adaptive responses to phenobarbital in putative pre-stages of liver cancer. Scanning STED-FCS reveals spatiotemporal heterogeneity of lipid interaction in the plasma membrane of living cells. Since human papillomavirus type 16 L1 virus-like particles (HPV16 VLPs) induce a potent, protective immune response after vaccination, we examined their recognition by DCs.

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The association between BMD and AAC seems to be age-independent, which suggests a common pathogenesis for bone loss and vascular calcifications. Changes observed in maternal activin A concentrations in mid and late gestation in the human may also be associated with fetal compromise. The mathematical framework for this new rotating frame of reference is presented based on time scaling the Bloch equation after transformation to the classical rotating frame of reference whose transverse plane is rotating at the Larmor frequency. Moreover, it was indicated that clone 4-9 could recognize the flexible region of the N-terminal domain of PrP.

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Following administration of the 500- and 750-mg/kg doses, the estimated average steady-state levels of anti-ClfA were 6.1 U/ml and 9.2 U/ml, respectively, and those of anti-SdrG were 5.2 U/ml and 7.7 U/ml, respectively. In heart patients with a normal final diastolic pressure in left ventricle and average left auricle pressure, pulmonary capillaries (PC) resp., the average values of all functional EchoC-indices are normal. Structural remodeling in the limb circulation: impact of obesity and diabetes.

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