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Aczone (Dapoxetine)

Aczone a selective serotonin reuptake inhibitor is a new chemical entity for the treatment of premature ejaculation. Since no systematic studies on design and development of Aczone hydrochloride tablets are available in literature, we propose to develop a suitable formulation to characterize in vitro release profile of Aczone hydrochloride. The aim of the present study was to formulate various formulations of immediate release tablets of Aczone Hydrochloride using different excipients by direct compression and wet granulation method. The granules and tablets of Aczone HCl were evaluated for various pre and post compression parameters like Angle of repose, Compressibility index, Hausner's ratio, Tablet hardness, Thickness, Friability, and chemical parameters. Punches of different size were used to obtain the desired shape, ease of swallowing of tablets, to improve aesthetic value in terms of appearance and shape of tablets. To match dissolution profile of test formulation with innovator, drug particle size is reduced from D 90-158 µ to D 90-45 µ, which resulted in an increased surface area exposed to the dissolution medium. Final formulation was evaluated for multimedia dissolution in three different media and dissolution data was found satisfactory. Accelerated stability studies conducted for 2 Months at 40°C and 75% RH and were found within specification.

Other names for this medication:
Dapoxetine, Actinex, Aczone, Dapoxetin, Dapoxetina, Dapsone, Dejac, Duraject, Duralast, Poxet, Priligy, Viglast, Westoxetin, Xydar,

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Onycholysis following the ingestion of psoralens and subsequent exposure to natural sunlight has been reported on several occasions and was first reported following photochemotherapy in 1978 by Ortonne and Baran from France and in 1979 by Mackie from Scotland. The following seven cDNA clones of particular interest were obtained: three clones putatively coding for part of the alpha-subunit of a stimulatory G protein (Gs), one clone putatively coding for part of the alpha-subunit of an inhibitory G protein (Gi) and three clones putatively coding for part of the alpha-subunit of a transducin (Gi)-like protein. Mutation analysis of the HBV reverse transcriptase in nucleos(t)ide-treated patients with chronic HBV infection KVLD does not inhibit platelet aggregation in contrast to the results recently published.

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Regional anesthesia techniques, arthrocentesis, saphenous vein cutdown, central venous and arterial cannulation, surgical airway, thoracostomy tube placement and thoracotomy were integrated into the appropriate practice stations. Performance of blue- and green-sensitive photoreceptors of the cricket Gryllus bimaculatus. Host factors, (e.g., antibody, lymphokines, immune interferon) influence intracellular rickettsiae. Instrumentation of periodontal pockets during treatment may result in bacteremia and/or endotoxemia. The basket consists of eight fibrils anchored to the NPC core by nucleoprotein Nup153.

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Combined flash- and glow-type chemiluminescent reactions for high-throughput genotyping of biallelic polymorphisms. In the past, simple excision of this tumor has been followed by rapid recurrence. In contrast, capillaries of suckled unaffected mice contained very few chylomicrons, and the subendothelial spaces and lung alveoli were free of chylomicrons. Depletion of cellular GSH by the inhibition of GCL activity using L-buthionine sulfoximine evidently eliminates the inhibitory effects of curcumin on HSC activation.

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The aim of this study was to investigate neurochemical alterations in the left DLPFC, considered a main area of pathogenesis in depression, using rats exposed to the forced swimming test (FST). References to either indigenous uses or the results of controlled assays are numerous for species of Phyllanthus (Euphorbiaceae). The lateral reticular nucleus (LRN) has been identified as an area in the caudal medulla involved in the centrifugal modulation of spinal nociceptive transmission and withdrawal reflexes.

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STUDIES ON FIGURE DRAWINGS: STRUCTURAL AND GRAPHIC CHARACTERISTICS. Individuals diagnosed with major depressive disorder exhibit an attentional bias toward negative emotional cues (e.g. The consideration of competition is especially relevant for species with low reproductive capacities to enable a realistic estimation of recovery pace. ARYEXP and GEOGSE contain 887 and 1064 unique chemical substances mapped to 1835 and 2381 chemical exposure-related experiment accession IDs, respectively. Effect of oxygen on L-arginine transport in pulmonary arteries in rats chronically exposed to hypoxia-hypercapnia

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Prospective study of hyperglycemia and cancer risk: response to Stattin et al. Phenacetin abuse V: number of phenacetin abusers in Basel autopsy material 1978-1980. Late-onset Bing-Neel syndrome associated with delirium and Lewy body dementia. Drug-induced inhibition of platelet function delays progression of peripheral occlusive arterial disease. Since ecotoxicity is likely caused only by the biologically active enantiomers, knowledge on isomer selectivity may improve our understanding of the ecological risks of CP and analogous SPs.

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Suture-line reinforcement with glutaraldehyde-preserved bovine pericardium for nonanatomic resection of lung tissue. It can be concluded that, to date, there is no single detoxification process that could be applied universally to all different types of mineral particles. The cell death protease caspase-2 has recently been recognized as the most apical caspase in the apoptotic cascade ignited during cell stress signaling. Persistent high levels of IgM antiphospholipid antibodies in a patient with recurrent pregnancy losses and rheumatoid arthritis.

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The effect of screening on mortality from breast cancer has been evaluated in four intervention (experimental) studies with random assignment, one intervention study with nonrandom assignment, three case-control studies, and one follow-up study. These elements include (i) the IFN-stimulated response element (ISRE) which is necessary for IFN-alpha-induced cellular gene expression, and (ii) an element located near the site of transcription initiation. Follow-up investigation in urologic oncology, in particular nephrectomy due to renal cell carcinoma While the genetic origin of Fabry disease (FD) is well known, it is still unclear why the disease presents a wide heterogeneity of clinical presentation and progression, even within the same family.

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The bacteria involved are Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus. We conclude that rebamipide is an important candidate for long-term suppression of gastro-intestinal inflammation, particularly if reducing the complications of H. Why circadian rhythms are circadian: competitive population dynamics of biological oscillators.

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Case of a combination of asthmatic pulmonary eosinophilia with thymus hyperplasia scalloped functions in a regulatory loop with vestigial and wingless to pattern the Drosophila wing.

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Bovine lactoferricin (LfcinB) is a cationic peptide that selectively induces caspase-dependent apoptosis in human leukemia and carcinoma cell lines. The family of inhibitor of apoptosis (IAP) proteins is a recently identified, novel category of apoptosis-regulatory proteins.

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The presence of a4 in the olfactory epithelium was further investigated and the additional presence of C2 and d2 subunits identified. Astrocytic glutamate uptake was also decreased by activated microglia or by added peroxynitrite.

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The acyltransferase (AT) domain in module 4 of the erythromycin polyketide synthase (PKS) was substituted with an AT domain from the rapamycin PKS module 2 in order to alter the substrate specificity from methylmalonyl-CoA to malonyl-CoA. In a prospective study of 613 patients with cirrhosis of different aetiological types increasing age, male sex, and non-UK nationality were found to be significant independent risk factors for the progression of cirrhosis to hepatocellular carcinoma.

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Type 2 diabetes is the most prevalent and serious metabolic disease affecting people all over the world. Thirty-three privately owned dogs with high-grade 2nd- or 3rd-degree AV block were included.

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A vinylogous tetrathiafulvalene (TTFV) monomer was prepared and copolymerized with fluorene to give a conformationally switchable conjugated copolymer. JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation. Anti-atherogenic effect of hydrogen sulfide by over-expression of cystathionine gamma-lyase (CSE) gene. Naturally occurring antibodies against fibrosarcoma and glioma cells in rats. In addition to receiving customary therapy, 61 patients were randomly assigned to receive atenolol, and 59 to receive placebo.

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The aims of this study were to translate the ALP scale into Turkish and to assess its psychometric properties with 890 adolescents between the ages of 14 and 18 years. One hundred and ten women students provided a total of 864 early morning urine samples, using a different sampling technique each morning. A working group of the South African Childhood Asthma Group was established to review the published literature on acute asthma in children from 2000 to 2012, and to revise the South African guidelines accordingly. DWI abnormality on immediate postoperative MRI is common following surgery for newly diagnosed intracranial mass lesions in pediatric patients. The impact of DOR technology on the operation of an imaging department is projected.

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Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis. The objective diagnosis of genital skin lesions caused by herpes simplex virus and human papillomavirus are remained to be developed. DDAVP, a synthetic analogue of vasopressin, in prevention of headache after lumbar puncture and lumbar pneumoencephalography.

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Thirty-two such procedures have been performed with only one complication, a small wound seroma. Therefore, VEGF expression in primary and secondary hair follicles is synchronized throughout the year, and is correlated to hair development. SUMMARY BACKGROUND INFORMATION: Delay in diagnosis of breast cancer is the most common clinical scenario resulting in malpractice litigation. Intraphagocytic protection of staphylococci from extracellular penicillin.

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Response inhibition was measured using the original Stroop task. Biliary shockwaves appear to cause few side effects under normal conditions but should be used with caution in patients with potential bleeding disorders.

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Although inflammation facilitates the wound healing process, chronic persistence over several decades results in scar accumulation, fibrosis and often cirrhosis. These observations support the distinction between dominance and aggression and strongly suggest that when hierarchical relationships are uncertain, serotonergic mechanisms may mediate the behaviors which permit a male to attain high dominance status. A behavioral training program consisting of visual and movement imagery exercises.

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Cell activation by the neurotransmitter is visualized using calcium imaging. Behavior of somatostatin-immunoreactive cells in the gastric mucosa before and after selective proximal vagotomy and pyloroplasty in treatment of gastric and duodenal ulcers. Research progress in live attenuated Brucella vaccine development. However, the role of erythrocytes in inducing the vulnerability of plaque with intraplaque hemorrhage and the possible mechanism involved are not well understood. ERP amplitudes were measured at four midline scalp sites (Fz, FCz, Cz, Pz).

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The analysis starts with the development of a master equation for the time development of P(m) . Marketing methods can be used to identify the potential population for hospice care. The distribution of beta-adrenergic receptor sites has been studied in chicken spinal cord and cerebellum using a fluorescent analogue of propranolol, 9-amino-acridin-propranolol (9-AAP). We used COMPARE analysis of chemosensitivity measurements from 39 human cancer cell lines and identified phosphatidylinositol 3-kinase (PI3K) as a molecular target for ZSTK474. After a single 40 mg subconjunctival injection an effective concentration was achieved in 2 hours and maintained for 24 hours.

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We previously identified a small basic leucine zipper (bZIP) protein, Jun dimerization protein 2 (JDP-2), that acts as a coregulator of the N-terminal transcriptional activation domain of progesterone receptor (PR). Enhanced external counterpulsation (EECP) could improve endothelium-dependent vasodilatation of carotid artery and restore imbalance of nitric oxide and endothein-1 in patients with coronary artery disease. Those schizophrenics with defect states, intellectual and neurological impairment, brain atrophy, neuropsychological impairment, and poor school and social premorbid adjustment do not respond as well to dopamine blockers. Maternal-fetal transfers: indications, appropriateness, and cost.

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The diagnosis was suspected when two groups of heart sounds at two distinct rates were heard on auscultation, and was confirmed by the postnatal ECG. Decompressive cystocentesis, in cats with urethral obstruction, followed by placement of an indwelling urinary catheter, did not result in a diagnosis of bladder rupture in any cat.

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These in vivo experiments were compared to in vitro measurements of fluphenazine-treated rats. MicroRNA-124 suppresses tumor cell proliferation and invasion by targeting CD164 signaling pathway in non-small cell lung cancer. Based on the limited data available, it appears that sildenafil, while well tolerated, offers little or no benefit to most patients with FSD. More specific antigen-directed peptide therapies have also been applied to atopic asthma, type 1 diabetes, and adult and juvenile arthritis.

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The immunoblot analysis of testicular microsomes showed two intense TFA protein bands of 63 and 59 kDa, whereas in liver three intense bands of 100, 76 and 63 kDa were observed. Laparoscopic procurement of right and left kidneys can be performed with comparable quality and outcome for donors and recipients.

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The apomorphine (1.0 mg/kg)-induced stereotypy was stimulated dose dependently by bromocriptine in 2-month-old-rats but not in 12-month-old rats. The vast majority of healthy subjects had detectable values of serum immunoreactive calcitonin (iCT) and elevated levels were found in patients with MCT. Chronic unilateral neglect from focal meningoencephalitis lesions in an immune-compromised hemodialysis patient.

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The fall in blood sugar occurring during infusion of ouabain (1 microgram per kilogram per minute for a 60-minute period) in dogs is accompanied by an increased uptake of glucose and potassium by the liver. Whether decorin may bind another member of the IGF-I system, the insulin receptor A isoform (IR-A) and its cognate ligands, insulin, IGF-II and proinsulin, have not been established. Our study demonstrates that gymnosperms do have FT-like and TFL1-like genes. In the Bax-deficient DU145 cell line only autophagy was observed. Blurred vision as the sole initial presentation of disseminated lung malignancy.

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To study the effects of thyroxine on orocaecal transit time in a group of elderly hypothyroid patients on long-term thyroxine replacement therapy. Use of intrathecal hyaluronidase in the management of tuberculous meningitis with hydrocephalus. We also performed an observer test to compare their diagnostic performance with VISIBLE, MPRAGE and only Black in 34 patients. To better understand the role of membrane interactions in amyloid formation, two-dimensional infrared (2D IR) spectroscopy was used to compare the kinetics of amyloid formation for human IAPP both in the presence and in the absence of negatively charged lipid vesicles.

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High TSH levels within the reference range may be associated with modestly higher future levels of blood pressure and adverse serum lipids. Surprisingly, both green and non-green plastids appear to contain a similar soluble Clp core proteolytic complex, consisting of five ClpP proteases, their non-catalytic ClpR homologs, and two ClpS homologs that have unknown function. All of the experimental results were reproduced by a numerical model. Reorganization and growth of metastable alpha-N2 critical nuclei into stable beta-N2 crystals. Micropatterning of proteins and cells has become very popular over the past decade due to its importance in the development of biosensors, microarrays, tissue engineering and cellular studies.

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Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. To determine whether the Northwick Park Care Needs Assessment (NPCNA) could be used to estimate nursing staff requirements in an inpatient rehabilitation setting. Of these, ten underwent lymphadenectomy and liver resection while one patient underwent resection of the cystic duct stump.

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We have synthesized a retinal in which the five protons closest to the Schiff base are replaced by deuterons. Twelve subjects were awakened four times in each of two experimental nights and alternately asked to recall, with or without concurrent verbalization, MSE contents preceding the awakening. The uptake of unbound daunorubicin was higher than that of doxorubicin. The classical notions of tumor diagnosis (classification and diagnostic accuracy) as well as the generally accepted criteria for evaluating the success of the tumor therapy (mortality graphs, survival time and remission) are submitted to a critical examination. Binding of the capsid protein of Venezuelan equine encephalitis virus (VEEV) to several types of RNA was used as a model system to test the application of the method.

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Gallen 2007 requires the following as a basis for risk-adapted therapy decisions: tumor size, stage, age, nodal status, hormone receptor status and Her2 overexpression or amplification status. Long-term follow-up of lesion-specific outcomes comparing drug-eluting stents and bare metal stents in diseased saphenous vein grafts. Seven SPECTs in the six patients performing the delayed phase showed diffuse patched patterns of hypoperfusion which improved on follow-up images.

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Trait-based approaches assume that simple functional traits influence fitness and life history evolution, but rigorous tests of this assumption are lacking, because they require quantitative information about the full lifecycles of many species representing different life histories. Psychopathological study of the schizophrenic experience of the end of the world The algorithms are constructed to minimize the objective function under this framework.

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Evaluating the performance of an edge detection algorithm for use in radioisotope imaging. How well do evolutionary trees describe genetic relationships among populations? In this report, we have isolated a PAC human genomic clone containing the human AMBN gene. We investigated the outcomes of patients who underwent different combination treatments. The amplitude of the b-wave remained stable during increases in mean arterial blood pressure (MABP) up to 225 mm Hg but decreased rapidly if the MABP was lowered below 55 mm Hg.

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Airborne fine particle mass concentrations (PM2.5) are used for ambient air quality management worldwide based in part on known cardiorespiratory health effects. This indicates that the N-terminal domain of syntaxin 3 contains information for its polarized localization. Digital epiluminiscence microscopy (DELM) was performed before sun exposure and 28 days and 1 year after the cessation of intense sun exposure.

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Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. One consequence of this intense competition is the diversity of antimicrobial compounds that most species of bacteria produce. Lipid raft organization and function in brush borders of epithelial cells.

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The urine of stone forming patients who had received treatment showed no difference in crystal volume from that of a similar group who had not been treated, and the same was true of a group bcs classification of esomeprazole vs omeprazole of stone forming patients studied before and 6 months after the start of treatment. Intensity noise of injection-locked lasers: Quantum theory using a linearized input-output method.

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A volcano shape is revealed for the curve of the representative O2 adsorption energies on the sheets vs. Fifty overweight middle school children with a body mass index (BMI) above the 95th percentile for age were randomized to medovir 400 dosage for amoxicillin lifestyle-focused, fitness-oriented gym classes (treatment group) or standard gym classes (control group) for 9 months. Paradoxical effects of melatonin on spontaneous neuronal activity in the striatum of sham-operated and pinealectomized rats.

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Complement activation (all parameters) was significantly decreased in serum incubated in well surfaces coated with maclar syrup recipes peptides. We performed a review of health economic evaluations of rubella and CRS to identify gaps in the evidence base and suggest possible areas of future research to support the planned global expansion of rubella vaccination and efforts towards potential rubella elimination and eradication. The relation of influenza epidemics in Ohio to primary pneumococcic pneumonia of the Cincinnati General Hospital, 1936-1949.

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Physical activity and health--continuing focus of interest for epidemiologic research. A retrospective multicentre pilot study was conducted in HIV-infected patients on cART treated for DLBCL with CHOP between 2002-2010 in three academic hospitals. Fluorescence sizodon plus schizophrenia medication resonance energy transfer studies on anthrax lethal toxin.

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The prepared PAAC-grafted and GOD-immobilized microcapsules showed a reversible glucose-sensitive release characteristic. Help at the last second--separation of a bridge using an SAE blade electrode and subsequent blocking with an SAE blocking attachment The ability to perform conditional knockouts and to generate stable transfectants in DT40 cells has ribavirin mechanism of action animation facilitated the study of general transcription factors such as TATA binding proteins, essential splicing factors such as ASF/SF2 and crucial polyadenylation factors such as CstF64, as well as a number of more specific regulators of gene expression. One of these factors was common to all disorders, and another was exclusive to TTM and SPD.

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This study investigated attitudes of Japanese aged care staff toward aggression by people with probitor drug testing dementia. Using a lacZ reporter fusion to the ywkA promoter, it was shown that ywkA was specifically induced by external malate and not subject to glucose catabolite repression. Based on the elucidation of structures and functionalities, heterologous production of carboxysomes has been achieved so far.

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CERTAIN ORGANIC SUBSTANCES AND THEIR EFFECTS UPON THE INCIDENCE OF DENTAL CARIES IN THE COTTON RAT. Parallel discrimination of subjective contours defined by norfloxacin mepha 400 erfahrungen babbel offset gratings. The frequency of comorbid psychiatric disorders may be over-estimated if the general prevalence of psychiatric disorders in terms of gender and age is not taken into account.

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To assess the efficacy of spinal manipulation for patients with low ansitec bula libbs pharmaceuticals back pain. Tyrosinase activities and dopachrome conversion activity were evaluated in extracts made from skins of 6-day-old mice that were mutant at the agouti and albino loci.

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We conclude that intra-articular bupivacaine-ketamine combination provides better pain relief than intra-articular ketamine after day care arthroscopic knee surgery. As a result, the mitochondria of these lansoprazole krka 15 mg embryos would reach a situation close to control on day 13 that could allow them to follow the normal mitochondriogenic schedule throughout a gestational period in which the mitochondrial differentiation process is critical. Stage-photometric determination of hemoglobin by means of cyanhemoglobin Surprisingly, IgG2 antibodies to equine erythrocytes caused phagocytosis by bovine neutrophils and peripheral blood monocytes while IgG1 antibodies failed to cause either phagocytosis or adherence. Exposure to polybrominated diphenyl ethers among workers at an electronic waste dismantling region in Guangdong, China.