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Azelone (Azelastine)

Azelone is an antihistamine administered in aqueous solution as a nasal spray. It exhibits histamine H1 receptor antagonist activity and is used as a racemic mixture. No difference in pharmacologic activity between its enantiomers has been observed. Azelone HCl is used to treat seasonal allergic rhinitis (e.g., hay fever) and perennial rhinitis (including runny nose, sneezing, and nasal itching). It is also used in eyedrops to treat allergic conjunctivitis. It is considered to be a very safe drug with no serious side effects. Azelone HCl has been known since 1980, but its first US Food and Drug Administration approval for use as a nasal spray was awarded to Meda Pharmaceuticals (Somerset, NJ) under the brand name Astepro in 2008. Since its first registration, the drug has been sold under many brand names and is now generic.

Other names for this medication:
Azelastine, Afluon, Allergodil, Astelin, Astepro, Asthafen, Azel, Azelastin, Azelastina, Azelone, Azen, Azep, Azeptin, Ketasma, Lastin, Optilast, Optivar, Otrivine, Phenergan, Rhinolast, Rinalin, Xanaes,

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In 2009 and 2010, cross-sectional anonymous surveys were carried out among medical undergraduate students. The influence on red blood cells (RBC) of two cancerostatic-(ZIMET 3106 and ZIMET 3393) and two immunomodulating agents (ZIMET 3164 and ZIMET 86/76) administered subcutaneously, or intraperitoneally in case of the radiolabelled N-mustard compounds, to mice, was studied by means of measurements of the radiolabelled compounds in blood, by cell electrophoresis, filipin-induced hemolysis of pretreated RBC and by scanning electronmicroscopy. This measure reflects the lateral development of the proximal transverse process. RELATIONSHIPS BETWEEN AUTHORITARIAN ATTITUDES IN DELINQUENT GIRLS AND THE AUTHORITARIAN ATTITUDES AND AUTHORITARIAN REARING PRACTICES OF THEIR MOTHERS. Elevated levels of miR-145 correlate with SMAD3 down-regulation in cystic fibrosis patients.

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Although this treatment is effective in eliminating the vasoconstriction mediated by noradrenaline, the contribution of other circulating vasoconstrictors to vasospasm could be as important. The numerous traumatic brain injury models were designed to study the nature of the human brain injury.

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To assess hand function and grip force (GF) control in non-neuropathic diabetic individuals using traditional hand function tests and instrumented handles that provide information about the underlying neural mechanisms controlling simple manipulation tasks. Can questionnaire reports correctly classify relationship distress and partner physical abuse? Histochemical classification of the fibre composition revealed that the treatment induced an increase in the relative number of fast-twitch a (FTa or type II A) fibres accompanied by a reduction of the fast-twitch b (FTb or type II B) fibres. Of seven assessable acoustic neuroma patients treated, hearing was stabilized in three and improved in two. A recombinant transposon vector carrying a mutant green fluorescent protein gene (GFP) and a polyhedrin gene was constructed.

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Effect of trifloxystrobin on hatching, survival, and gene expression of endocrine biomarkers in early life stages of medaka (Oryzias latipes). Long-term effects of magnetically targeted ferumoxide-labeled human neural stem cells in focal cerebral ischemia. A variety of the anticonvulsant drugs, including carbamazepine, phenytoin, primidone, phenobarbital, clonazepam, valproic acid, and ethosuximide, are available for use in the treatment of patients with seizure disorders.

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High-resolution DNA melting analysis with saturation dyes for either mutation scanning of PCR products or genotyping with unlabeled probes has been reported. From these studies a drug evaluation protocol was developed using 150 NaL3 as the infectious dose and then evaluating the anthelminthic effects of the drugs albendazole, tribendimidine, and pyrantel pamoate on days 21-28 post-infection. Preclinical and initial clinical trials with allogeneic MPCs have been encouraging, providing the support for a large ongoing Phase III trial-DREAM-HF. Effects of cholecystokinin and metoclopramide on jejunal movements of water and electrolytes and on transit time of luminal fluid in man.

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Aureomycin and rachicentesis in the treatment of severe whooping cough It was recently shown that Nrf1 is regulated by SCF-Fbw7 ubiquitin ligase. Lysosomal arylsulfatases A and B (aryl-sulfate sulfohydrolases, EC from horse leukocytes were purified about 680-fold and 70-fold, respectively, starting from a crude extract of the azurophil and specific granules of leukocytes, by affinity, ion exchange, and gel filtration chromatography. Status and prospects for neuroendocrine research in the physiology of reproduction

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During prolonged intervals of wakefulness, brain adenosine levels rise within the basal forebrain and cortex. Ecto-hydrolysis of adenine nucleotides in rat blood platelets are altered by ovariectomy. These results demonstrated that thyme oil alone showed more effective potential to improve intestinal barrier integrity and antioxidant status as well as evoking an immune response in chickens, than if diets were supplemented with both thyme oil and selenium.

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Relationships among the detection of p24 antigen, human immunodeficiency virus (HIV) RNA level, CD4 cell count, and disease progression in HIV-infected individuals with hemophilia. The disparate effects of unsaturated fatty acids and sterols on these strains lead us to consider the possibility of separate, compartmentalized isoprenoid pathways in S. Rate of apparent magnification as a cue to distance: laboratory investigation. Long-lasting muscle relaxant activity of eperisone hydrochloride after percutaneous administration in rats.

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