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Etabus (Disulfiram)

Etabus is a drug that has been used as a deterrent agent in the treatment of alcohol use disorders. This section ventures into the journey of the discovery of the molecule, starting from the accidental discovery of its potential pathophysiological effects, thereafter becoming obscure due to lack of indications (alcohol use was not considered a problem!); and finally making a comeback and standing the rigorous test of time due to the determination of a few researchers, which makes it a story worth revisiting.

Other names for this medication:
Disulfiram, Antabuse, Anticol, Aversan, Esperal, Etabus, Tenutex,

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The stoichiometry and thermodynamics of binding of the bacteriophage P22 scaffolding protein within the procapsid were analyzed by light scattering and isothermal titration calorimetry. Perforin and granzyme B: predictive markers for acute GVHD or cardiac rejection after bone marrow or heart transplantation. Investigation of cellular phosphorylation and signaling pathway has recently gained much attention for the study of pathogenesis of cancer.

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Seven symptomatic subjects (3 male and 4 female: ages 18-64 years, mean 45) with clinical features of ARVD (typical ventricular arrhythmias) underwent comprehensive noninvasive assessment including transthoracic echocardiography (TTE), nuclear magnetic resonance (NMR), and TEE. The use of the combination was shown advisable in the complex therapy and prevention of relapses in patients with streptococcal infections.

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The isolates of CMV were characterized by the method of DNA restriction analysis. In contrast, stimulation of endothelial cell capillary morphogenesis with PMA enhanced TEM7 expression. The leu5-enkephalin analogues were more potent in their effects on the mouse vas deferens than they were on the guinea-pig ileum. Sex pili and the classification of sex factors in the enterobacteriaceae. Intestinal ischemia-reperfusion (IIR)-induced gut injury remains a challenge for critically ill patients despite the oxidative stress theory that has been elaborated.

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Change in condylar long axis and skeletal stability following sagittal split ramus osteotomy and intraoral vertical ramus osteotomy for mandibular prognathia. Insulin-deficient diabetes was induced by streptozotocin (STZ) in transgenic skinny mice overexpressing leptin. In the aerobic intestinal microflora there was a decrease in the numbers of Escherichia coli while no changes occurred in the anaerobic microflora.

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Measurement of cervical range of motion (CROM) by electronic CROM goniometer: a test of reliability and validity. Thoracoscopic segmentectomy could achieve equal short-term surgical results and long-term oncological outcomes compared with thoracoscopic lobectomy. The I-V curve of the film is depicted in vertical direction using electrode of aluminum film plated on the surface of the diamond films.

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Early mechanisms of gravity sensing studied in characean rhizoids during parabolic flights. The pulmonary vein ablation catheter (PVAC) is designed for pulmonary vein isolation (PVI). The position of the ferromagnetic transducer in the middle ear and the presence or absence of an additional coupler could be determined in this study.

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Overall, these results indicated developmental PCB exposure can alter the motor-stimulating effects of repeated AMPH injections. In this study, we show that PINK1-dependent Parkin mitochondrial recruitment in response to global mitochondrial damage by carbonyl cyanide m-chlorophenylhydrazine (CCCP) requires active glucose metabolism.

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Pathogenic microorganisms have apparently evolved defence mechanisms that counteract the effects of NO and related reactive nitrogen species. Rampant caries is an advanced and severe dental disease that affects multiple teeth. Due to the recent advances of next-generation sequencing technology, several effective methods have been developed for high-throughput analysis of DNA methylation, enabling DNA methylation markers to be innovative diagnostic and therapeutic strategies in cancer. Validity, reliability and reproducibility of plain radiographic measurements after total hip arthroplasty. Electron microscopically degenerating terminals in the dorsal part of the ipsilateral LGN can be identified as cortical afferents.

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The term schizotaxia is currently defined as a syndrome of neuropsychological deficits and negative symptoms found in relatives of schizophrenic patients. The xylazine-induced delay of small intestinal transit was antagonized by alpha 2-adrenoceptor antagonists, e.g., yohimbine, piperoxan and tolazoline. An RNase protection assay revealed that the transcript level of the wild type relative to that of the reverse promoter mutant at the downstream regions was much lower than the level at the upstream regions. subnigricans should be considered in the mushroom poisoning with rhabdomyolysis. Bisphosphonates may induce direct anti-tumor effects in breast cancer cells in vitro.

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They point out particularly the value of ultrasound and frozen section histological examination. Backtable heat-enhanced preconditioning: a simple and effective means of improving function of heart transplants.

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The isoelectric point, optimal pH and temperature, Michaelis constants for several substrates and inhibition constants for glucose and glucono-delta-lactone of each enzyme were determined. The effect of the specific alpha 2-adrenoceptor agonist BHT 933 on stimulated renin release was investigated in the isolated perfused rat kidney preparation.

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SIRT1, an enzyme regulating metabolic circuits linked with obesity, has a cardioprotective effect and is a predictor of cardiovascular events. Paracoccidioidomycosis is a systemic form of mycosis that spreads hematogenously, secondarily to reactivation of lung infection or infection at another site or to new exposure to the causative agent.

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Maternal transmission of HTLV-1 other than through breast milk: discrepancy between the polymerase chain reaction positivity of cord blood samples for HTLV-1 and the subsequent seropositivity of individuals. On the interpretation of binding isotherms in complex biological systems.

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