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Kivexa (Abacavir)

Kivexa is an oral medication that is used for the treatment of infections with the human immunodeficiency virus (HIV). It is in a class of drugs called reverse transcriptase inhibitors which also includes zalcitabine (Hivid), zidovudine (Retrovir), didanosine (Videx), lamivudine (Epivir), emtricitabine (Emtriva), and stavudine (Zerit). During infection with HIV, the HIV virus multiplies within the body's cells. The newly-formed viruses then are released from the cells and spread throughout the body where they infect other cells. In this manner, the infection continually spreads to new, uninfected cells that the body is continually producing, and HIV infection is perpetuated. When producing new viruses, the HIV virus must manufacture new DNA for each virus. Reverse transcriptase is the enzyme that the virus uses to form this new DNA. Specifically, Kivexa is converted within the body to its active form (carbovir triphosphate). This active form is similar to a compound (deoxyguanosine triphosphate), a chemical that is required by the HIV virus to make new DNA. The reverse transcriptase uses carbovir triphosphate instead of deoxyguanosine triphosphate for making DNA, and it is the carbovir triphosphate that interferes with the reverse transcriptase. Kivexa does not kill existing HIV virus, and it is not a cure for HIV. The FDA approved Kivexa in December 1998.

Other names for this medication:
Abacavir, Abalam, Epzicom, Kivexa, Abamune, Virol, Ziagen,

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Ab initio calculation of the low-lying vibrational states of C2H2(A) in full dimensionality. Aminooxyacetate (an inhibitor of transamination of leucine) partially depressed the stimulating effect of leucine on p-aminohippurate accumulation, whereas alpha-ketoisocaproic acid (a metabolite of leucine formed by transamination) enhanced p-aminohippurate accumulation, suggesting that the metabolism of leucine in kidney slices may be necessary for the stimulating effect on p-aminohippurate transport. The mono or dicationic moiety is connected to the phosphate group by an aryl spacer.

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Effects of bayberry juice on inflammatory and apoptotic markers in young adults with features of non-alcoholic fatty liver disease. This review will summarize the literature surrounding the molecular effects of cannabinoids and opioids on the locus coeruleus-norepinephrine system, a key circuit implicated in the negative sequelae of opiate addiction. Drinking specifically for intoxication was also a positive outcome for males in particular. Within the limits of this study, it was concluded that solder material might negatively affect porcelain-metal crowns. After treatment, the abscess cavity became homogeneously hypointense on T1-weighted images, corresponding to liquefaction of the abscess center.

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Observational, cross-sectional study examining differences between intramural (IM) and interscholastic (IS) sports. The objectives of this study were to determine the HP prevalence and NSAID/ASA use in patients with bleeding ulcer in a low-prevalence HP area, to determine the proportion of idiopathic ulcers and to estimate the proportion of initially false negative HP tests. As home medication use increases, medications previously managed by nurses are now managed by patients and their families. There was no significant difference between the two groups in terms of implantation and pregnancy.

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The inbred mouse strain C3H/He exhibits spontaneous absence seizures characterized by spike and wave discharges (SWD) on the electroencephalogram concomitant with behavioral arrest. In a preliminary clinical study using resected tissues from head and neck SCC patients, KITENIN was highly expressed in tumors and metastatic lymph nodes, while KAI1 was more increased in adjacent mucosa than in tumor. Multiple regression analyses indicated that litigation was not the primary predictor of downtime or medication use. The purpose of this report is to draw the attention of clinicians to the possibility of metastatic RCC in patients with recurrent epistaxis and nasal mass. Corticotropin-releasing factor (CRF) acts within the brain to elicit changes in neuroendocrine, autonomic, and behavioral activity similar to those observed after stress.

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Transplacental transfer of rodent microfilariae induces antigen-specific tolerance in rats. In contrast to previous work, we utilize an objective measure, the Normalized Probabilistic Rand Index, which takes into account the variations in the ground-truth images. Measurement of light transmission or impedence should have been included in platelet study. The importance of the routine examination for preoperative preparation Some of the more serious side effects, particular tardive dyskinesia, require that clinicians use these drugs only in situations when they are demonstrably effective, and at the lowest effective dose.

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Gla domain-mediated protein-membrane interaction is required for generation of thrombin, the terminal enzyme in the coagulation cascade, on a physiologic time scale. To explore the impact of combination use of prostaglandin analogue and cholinergic agonists on main matrix metalloproteinases (MMPs) synthesized by albino rabbit ciliary muscle. Potentially even more problematic for preserving tissue homeostasis, neighboring osteoarthritic chondrocytes display strong heterogeneity in their phenotype, gene expression patterns, and cellular responses. We observe significant differences in the reproductive plan and behaviour between the Bulgarian and Turkish population.

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Oncological outcomes of renal pelvic and ureteral cancer patients registered in 2005: the first large population report from the Cancer Registration Committee of the Japanese Urological Association. Nineteen mildly or moderately retarded subjects were presented 32 oddity-training trials per day for 10 days with all new etimuli presented on each trial. Effectiveness of transtympanic neurectomy in management of sialorrhea occurring in mentally retarded patients.

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Awake nasotracheal fiberoptic intubation requires an anesthetic management that provides sufficient patient comfort, adequate intubating conditions, and stable hemodynamics. Magnesium supplementation could improve erythrocyte insulin receptor affinity and improve insulin resistance in type 2 diabetic rats. Structure and synthesis of nectrisine, a new immunomodulator isolated from a fungus. Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH.

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Composition of chromosome fragments participating in phage P22-mediated transduction of Salmonella typhimurium. (Platyhelminthes, Turbellaria, Tricladida), has been studied by light and electron microscopy. In the present study, we investigated the miRNA expression profiles of various muscular tissues.

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The RUK infusion produced an increase in urinary excretions of nitric oxide and cyclic guanosine monophosphate. Music listening and cognitive abilities in 10- and 11-year-olds: the blur effect. Digital cineradiology in the diagnosis and surgical treatment of pharyngo-oesophageal junction motor disorders Solvent-free methallylboration of ketones accelerated by tert-alcohols. Results showed that the TWAA conditioning alone increased the expression of the two analysed IEGs in several hippocampal areas, and TWAA retention increased Nurr1 expression in amygdala.

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Capsule studies were identified from a master database of funded studies. A systematic review: effectiveness of rectal emptying preparation in prostate cancer patients.

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Study on the mechanisms and influential factors of intrauterine infection of hepatitis B virus After every change of position of the patient, especially after flexion or extension of the head, the position of the tube must be checked again. Localization of breast cancer susceptibility loci by genome-wide SNP linkage disequilibrium mapping.

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ASSOCIATION OF THE LYSOSOMES OF THE RETICULOENDOTHELIAL SYSTEM WITH MOUSE ANAPHYLAXIS. Defects in viability and oogenesis were consistently more severe in rbp Met or br Met double mutants than would be expected if these genes act independently. Insertion of genetic material into the hematopoietic cells of mammals Two types of aneurysms are distinguished: parencchymal and pseudocysts.

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This case report describes the natural history of chronic cadmium intoxication in a woman who was exposed to excessive cadmium in her occupation. The results pointed to the well-adjusted reliability and validity of MASSQ and its usefulness for the relevant studies as well. Application of microfluidic gradient chip in the analysis of lung cancer chemotherapy resistance. It was hoped that the solution structure of this enzyme would provide virex tablets apple further details about the conformation of this key region and give new insights into the functional properties of these enzymes.

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