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Adult bone marrow-derived stem cells and the injured heart: just the beginning? Because no current evidence-based guidelines for postmenopausal hormone therapy (HT) discontinuation strategies exist, we compared female veterans who tapered HT to those who stopped abruptly with regard to patient-specific health factors and recurrence of menopausal symptoms.

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Together with transcriptome data, specific genes from a set of alternatives have been mapped onto different pathways. To our knowledge, this study provides the first evidence of a de novo CRE in mammals that produces a systemic functional effect.

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DNA sequence variants of the H1 gene have been mapped to individual P1 clones and found to be in a partitioned organization. MDC1 forms a complex with Rad51 through a direct interaction with the forkhead-associated domain of MDC1, not the BRCA1 C-terminal domain. A 74-year-old man with a right inguinal hernia since 15 years was admitted because of inguinal pain and enlarged ipsilateral testis.

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Adverse effects of aspirin in the treatment of asymptomatic carotid artery stenosis. 2) Pre-retention morphine 5, 10 mg/kg disrupted the retrieval of memory after 1 h ITI. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. Anatomical results improved after EBM for posterior retinal detachment in silicone oil filled eyes associated with myopic macular hole, which was not evident for visual outcome. Furthermore, with the exception of un-24, all of the putative het genes identified occurred mostly in a multi-copy fashion, some with lineage and species-specific expansions.

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In this study we investigated the effect of Taxol, radiation, or Taxol plus radiation on highly proliferative normal tissue--the intestinal crypt cells of Swiss albino mice. The patient was treated with meropenem, which was considered as one of the best available agents, however, he required a prolonged antimicrobial treatment. Surgical approaches to atlanto-axial lesions are generally accomplished by either anterior (transoral) or posterior approaches as dictated by the location of the lesion. Significantly lower levels of gamma-globulins, specifically IgG and IgA, were detected in the plasma of patients with severe OHSS, whereas alpha- and beta-globulin levels as well as IgM levels were not significantly different from those in controls. Although the salivary glucose levels were almost constant in all age groups, secretory immunoglobulin A and lactoferrin levels in saliva were significantly decreased statistically with age, and a marginal age-associated decrease in transferrin levels was also observed.

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The results of our study suggest that the efficacy of rufinamide in patients with generalized epilepsy might be comparable to that in patients with LGS, whereas rufinamide was less effective in patients with partial epilepsy. Mice were randomized into three groups: vehicle control and two daily intraperitoneal (-)-gossypol treatment groups (5 and 15 mg/kg). We found that gbpC expression attains the maximum level at mid-exponential growth phase, and the half-life of the transcript is less than 2 min.

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In order to understand the structural basis of interaction of various Smads with their target proteins and the promoter DNA, we modeled MH1 domain of the remaining mammalian Smads based on known crystal structures of Smad3-MH1 domain bound to GTCT Smad box DNA sequence (1OZJ). P values were derived from 1,000 permutations, and empirical P values for global significance also were applied. We describe a molecular automaton, called MAYA, which encodes a version of the game of tic-tac-toe and interactively competes against a human opponent. sequential filgrastim and molgramostim after dose-intensified carboplatin, cyclophosphamide, and etoposide: a phase I pilot study. An increase of the optical density of the fractions showing a relatively high density was observed, which may be related to the well known changes of muscle glycogen levels after denervation.

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There are other conditions where patients can benefit from sustained duration of action following a single instillation, but achieving this has been difficult in nanosized carriers. The diabetes online community: the importance of forum use in parents of children with type 1 diabetes. A review of proton nuclear magnetic resonance spectroscopy studies of focal and global cerebral ischemia in rats is presented here. This inhibition of transduction is observed with several AAV serotypes and a number of primary and immortalized cells. A preliminary study of acute toxicity was performed to determine suitable dosing regimen/dose levels for future repeated-dose toxicity studies.

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Crystallization and preliminary X-ray analysis of FliJ, a cytoplasmic component of the flagellar type III protein-export apparatus from Salmonella sp. In response, we designed and implemented a program to respond to this problem.

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Ex post facto design with the uninvolved limb serving as the control. They then review aspects of the case pertinent to our local practice environment that make diagnosis and management especially challenging. Other endpoint measures included headache response rate, pain-free assessments, reduction in headache intensity, time to resumption of normal activities and consistency of headache response. In this study, using prostaglandin E2 production as a measure of stimulation, we quantitatively compared the ability of anakinra, as well as that of IL-1Ra delivered by gene transfer, to inhibit the biologic actions of IL-1beta.

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The results of the study are consistent with the hypothesis that in some patients interstitial myocarditis may produce left ventricular dilatation of a duration sufficient for the development of myocardial hypertrophy and EFE. The possible role of proton-coupled electron transfer (PCET) in water oxidation by photosystem II. Human herpesvirus 6 (HHV-6) isolates are classified into two variants, termed HHV-6A and HHV-6B, on the basis of distinct genetic, antigenic and biological characteristics, but the specific pathogenicity of each variant remains poorly understood. The facts that Se is toxic at low levels to Xenopus embryos and tadpoles, can cause developmental abnormalities, and accumulates in tissues suggest that increased release of Se compounds into the environment poses a potential threat to aquatic organisms. The designed index based on the reference model will be effective to quantitatively evaluate the recovery of motor skills for natural stroke in the virtual tennis task.

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Intraoperative or postoperative complications were taken into account. To present our experience in the management of 22 patients with thoracolumbar spine tuberculosis (TB) using a chemotherapy regimen and locally custom-made spinal brace. Perioperative continuous peripheral nerve blocks with disposable infusion pumps in children: a prospective descriptive study. Capturing interfacial photoelectrochemical dynamics with picosecond time-resolved X-ray photoelectron spectroscopy. Paradoxical pharmacodynamic effect of atropine on parasympathetic control: a study by spectral analysis of heart rate fluctuations.

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As a consequence of an increased awareness of quality management in psychiatry the Lundbeck Institute has developed a software program called Psychiatry Quality Measurement (PQM). Intercellular communication by the direct trafficking of transcription factors has been reported in plant developmental events such as root radial or epidermal cell patterning and shoot organogenesis. In addition, the status of predictive models building and some specific features of the eTOX predictive system (eTOXsys) are presented as decision support knowledge-based tools for drug development process at an early stage. This reaction was used to investigate a possible involvement of the vaccine strain in cases of abortion.

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Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. Clinicians need to know that the administered drug is compatible with both the PD solution and its container. Theoretical investigation of neutron scattering cross sections in Si and Ge. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation. The intravesical electrostimulation technique is designed to induce a voiding bladder contraction by direct stimulation as an immediate objective and for bladder retraining.

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Neuroglial synapses have been systematically observed in histotypical cerebellar rotary tissue cultures. Here we show that MyoR mRNA is progressively induced during the course of Tfh-like cell differentiation in vitro and is expressed in Tfh responding to Alum-precipitated antigens in vivo.

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Laparoscopy as a minimally invasive approach may offer a better opportunity to evaluate the role of anterior crossing vessels in UPJ obstruction. Polyethylene glycol solution (Kleanprep) and sodium picosulphate with a magnesium citrate solution (Picoprep) are bowel cleansing agents registered and available for this purpose.

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It plays an important role in the regulation of cellular growth. All subjects were evaluated using the Rivermead Mobility Index, Performance Oriented Mobility Assessment, and modified Activities Specific Balance Confidence scale.

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Over and above this, it enables comparison of patient groups of different hospitals. Surveillance for hepatocellular carcinoma (HCC) is considered a standard of care for patients with chronic liver disease who are at risk of developing this malignancy. We report a case of a 50-year-old patient with metastatic colon cancer who was referred with multiple Clostridium septicum liver abscesses. The perikaryal labeling was prevented in all cases by intraventricular administration of colchicine 1 day before the isotope injections.

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Effect of long-term administration of an analog of growth hormone-releasing factor on the GH response in rats. Despite rising numbers of interventions targeting obesity-prevention and treatment in preschool-aged children, there is no consensus for which tools represent a gold standard or threshold of accuracy. To investigate the ocular complications in pediatric bone marrow transplantation (BMT) patients. Postnatal expression of adipose tissue metabolic activity associated with a porcine genetic obesity.

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In Italy, a quality assurance system in radiotherapy should be applicable to the over 90 centers now operating with about 170 high energy units, 600 radiotherapists, 200 physicists and 600 technicians who treat over 100,000 patients per year. Further, requirements may be needed to improve its sensitivity and specificity. This index is based on temporal changes in the projected area of the cells and cell aggregates during the course of the experiment. We hypothesize that in addition to HIF-2alpha dysregulation, abrogation of additional pVHL functions is required for the initiation of renal carcinogenesis.

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Five pairs were used in a pilot study and 45 pairs were used in the main experiment. In the present study, the effect of amifostine and WR-1065 on neuroblastoma tumor growth and its protective potential for hematotoxicity were investigated. To investigate the clinical characteristics of patients with idiopathic optic neuritis (ON) in Taiwan and to assess the conversion rate to multiple sclerosis (MS) in these patients.

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Primary malignant mesothelioma of the penis: case report and review of the literature. Differences in hazard rates for 6-month mortality after stroke at population level were also found. The mechanism of DSB detection remains unclear although many candidate sensor proteins have been identified through cytologic, biochemical and genetic studies. When pyrenyl-labelled actin, at intermediate stages of polymerization, is diluted in the polymerization buffer, the decrease of fluorescence takes place stepwise through pseudo zero order reactions of decreasing rate.

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We report the clinical and imaging findings of a rare hepatic arteriovenous malformation in an infant presenting with high-output cardiac failure and pulmonary artery hypertension that was successfully treated by transarterial embolization using Onyx. Synthesis and antimicrobial activity of substituted fluorobenzyl benzylidenethiazolidinediones and imidazolidinediones To analysis the dissemination of integrons in the extended-spectrum beta-lactamases (ESBLs) producing Escherichia coli, isolated from stool specimen of chicken and to study the relations between the resistance and the integrons of these isolates. In many cell decision processes the underlying networks behave as bistable switches, converting graded stimuli or inputs into all or none cell responses. Significant differences in whole brain weight, a disproportionately decreased cerebellar weight, altered balancing ability, and a decreased number of cerebellar cells were observed on days 17 and 70 postnatally in both ethanol-treated groups as compared with controls.

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In both groups, persistent columnar or heterotopic columnar epithelium, not seen in the control mice, was identified and associated with adenosis. After grafting, animals were tested for methamphetamine-induced circling behaviour. Performing a cognitive task while walking results in a reduction of walking performance among persons with MS. Using PFGE to measure the molecular weight profiles, our fracture studies at high strain rates demonstrate chain halving and quartering in accordance with the predictions of the thermally activated barrier to scission theory for single-chain polymers. Problems presented by pulmonary tuberculosis in patients over fifty.

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These data suggest a correlation between catalase activity and survival following gamma-ray exposure. The total percentage recovery of the permeability markers was determined by high performance liquid chromatographic assays of urinary aliquots. This concept has come to fruition with estrogens, with the successful marketing of drugs such as raloxifene. The relative frequency with which the various types of carcinoma in situ are seen is in part explained by the ubiquitous nature of squamous metaplasia in the region of the transformation zone in women of reproductive age. The addition of low-dose theophylline increased HDAC activity and further reduced IL8 and TNFalpha concentrations.

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The proposals were discussed at a meeting held on 13 January 1999 by a large group of French microbiologists and clinicians who specialize in infectious diseases. Compared with the continuous infusion group, the automated intermittent boluses group for continuous fascia iliaca block can provide better analgesic effect , with less remedial analgesia.

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The fever subsided in a few days, but recurred together with development of icterus a few weeks later, precipitating this hospitalization. To establish a gas chromatography/mass spectrometry (GC/MS)-based metabolomics method to compare the metabolites in the follicular fluid (FF) from patients with in vitro fertilization (IVF) and repeated IVF failure (RIF).

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Total pancreatectomy and islet auto transplantation is a good option for chronic pancreatitis patients who suffer from significant pain, poor quality of life, and the potential of type 3C diabetes and pancreatic cancer. A survey was sent by mail and e-mail to a random sample of 1,000 members of the American Society for Clinical Oncology.

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It is not known whether the antimicrobial agent triclosan induces a significant acute phase reaction when bonded to vascular prostheses. A significant enhancement was seen at 1 nmol/l, which increased to a maximum level (over 4-fold) at 30 nmol/l. Perioperative risk factors pertinent to development of bile leakage were investigated using univariate and multivariate analyses. They can cause several environmental infections, such as conjunctivitis, otitis externa, wound infections, pneumonia, and gastrointestinal illness.

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In AS, clinical manifestations appear similar in men and women, whereas radiological features appear more frequent and severe in males. These results demonstrate that despite normal levels of HDL-C, apoA-I deficiency is associated with a significant loss of protection from the formation of atherosclerosis in LDLR-/- mice fed a chow diet. Effect of holmium laser enucleation of prostate on overactive bladder symptoms and urodynamic parameters: a prospective study. Marked healing-promoting action of cimetidine on acetic acid-induced ulcer in rats with a limited food-intaking-time.

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Implementing hospital-based communication-and-resolution programs: lessons learned in New York City. A regular follow-up in cystic fibrosis clinical centre is essential all life long. Results suggested that the three subspecific taxa within Coryphantha robustispina are good subspecies but should not be elevated to species rank.

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Protein biomarker discovery in blood plasma and serum is severely hampered by the vast dynamic range of the proteome. Some mf showed also disintegration of the myofilaments and of the internal structure of the mitochondria in the muscle cells. Fifty-two stroke patients with mild or without cognitive impairments and their primary caregivers voluntarily participated in this study. The median rate of weight loss was -1.87 kg per month (1 pound per week) for individuals later diagnosed with AN, while the median weight change was 0.24 kg per month for the Add Health dieters, reflecting an actual gain of 0.13 pounds per week.

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Time-dependent effects of hormone-deprivation therapy on prostate metabolism as detected by combined magnetic resonance imaging and 3D magnetic resonance spectroscopic imaging. The yield of attached DNA, its distribution in a CsCl density gradient, and its renaturation properties are essentially the same for interphase and metaphase chromosomes. After harvesting the flap, several smaller skin paddles were transferred and rejoined at the recipient site. The role of extraesophageal reflux (EER) in such disorders is underdiagnosed due to the often silent symptoms and difficult confirmation of diagnosis. To describe a practical method of aiding nasotracheal intubation in a cleft palate patient with previous pharyngoplasty using a suction catheter under tactile guidance.

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Instructive signals mediated by changes in resting potential control proliferation, differentiation, cell shape, and apoptosis of stem, progenitor, and somatic cells. The comparison between these two lines of research, in particular their different goals and approaches, is instrumental to explain the computational implications of the hypothesized modular organization. The structural aspects of the system that have been considered here include the inhomogeneous density profiles of ions and water molecules, hydrogen bond distributions, orientational profiles, and also vibrational frequency distributions in the bulk and interfacial regions.

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Synthesis of 3-hydroxy-3-(hydroxymethyl)-5-methyl-1,2-cyclohexanedione, a hydrolytic product of leucogenenol. Visualising the onset of viscous fingering in chromatography columns. Resolution of the human sex hormone-binding globulin dimer interface and evidence for two steroid-binding sites per homodimer. Simplified high performance liquid chromatographic method for the determination of clonazepam and other benzodiazepines in serum. Translation and validation of the wound-specific quality of life instrument Cardiff Wound Impact Schedule in a Swedish population.

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One additional patient had evidence of ischemia of the brain in the territory distal to ligation (steal), and in another both mechanisms were considered as operative hazards. Aged dopamine neurons appear to retain the ability to increase synthesis and release of dopamine in the presence of an appropriate pharmacological stimulus. Indeed, we may be caring for people with different spiritual beliefs from our own. Dexamethasone intravitreal implant as adjunct therapy for patients with wet age-related macular degeneration with incomplete response to ranibizumab. Contrast-unloading week in the complex therapy of patients with metabolic-alimentary obesity and its effect on changes in body weight and lipid metabolism indices

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Omentin, a recently found adipocytokine, is reported to regulate insulin sensitivity. For several of the neurotoxicants examined, significant effects were observed at similar concentrations between assays. Prolonged administration of imipramine (IMI)-the most often used antidepressant drug-increases the level of this peptide in the NAS and reverses the effect of CMS, when administered simultaneously to the animals subjected to CMS. We conducted a comparative ecosystem analysis of the Georges Bank and North Sea fish communities to determine the extent to which biological diversity is restored when fishing pressure is reduced.

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The eigen functions of this spectroscopic Hamiltonian are rewritten as semiclassical wave functions and transformed to a representation that allows us to analyze and assign the spectra with no other work other than to utilize concepts from nonlinear dynamics. Staphylococcus spp.-induced production of IFN-gamma required the presence of endogenous IL-18, IL-12, and TNF. Cholesterol homeostasis of skin fibroblasts after incubation with postabsorptive and postprandial lipoproteins. A comprehensive classification of contrast agents currently used or under development for magnetic resonance imaging (MRI) is presented.

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Our data suggest that BEI analysis provides a useful means of assessing nutritional status and was correlated with anthropometrics and biochemical findings. A simulation program has been developed for this purpose, which simulates the sensor output, for a moving object on the target plane at a specified distance from the sensor. Proteases therefore act as regulatory hubs that integrate information that the cell receives and translate it into precise outgoing signals. In GN, TrkA is overexpressed, whereas p75 did not show any difference versus C.