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Sustained agonism by beta1AR autoantibodies elicited caspase-3 activation, cardiomyocyte apoptosis, and DCM in vivo, and these processes were prevented by in vivo treatment with the pan-caspase inhibitor Z-VAD-FMK. Discipline-specific publications are not currently well covered by major indexing services, and those wishing to conduct comprehensive literature searches should search multiple resources.

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Atropine inhibited this effect, suggesting the phenomenon was mediated by direct cardiac parasympathetic nerve stimulation by the intracardiac shock. The quantitative determination of total phenols, ellagic tannins and gallic and ellagic acids in the peel of the Tunisian pomegranate variety Chelfi, has been carried out. Pantothenate-deficient cells provided with exogenous fatty acids synthesize additional lipids and express nearly normal solute transport activities. The high stain density in the smaller particle is consistent with the presence of a penetrating pore in this structure. To examine potential sources of errors at each step of the described inpatient International Classification of Diseases (ICD) coding process.

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An additional requirement for autaptic DSE is filled internal calcium stores. Cognitive disturbance in outpatient depressed younger adults: evidence of modest impairment. This article has provided an overview of the complex relationship between family therapy and child and adolescent psychiatry. The objective of this study was to evaluate the role of local oxygen tension in the zone-specific hepatotoxicity due to allyl alcohol. EVAR 2 showed that high-risk patients do not benefit from elective endovascular repair.

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Extraction with organic solvents or silicic acid and pre-dialysis against defatted human albumin produced no significant removal of the binding defect. For decades, it was presumed that microglia were stationary, inactive immune cells in the brain, waiting for an immunologic insult to call them into action. Possible predisposing factors for urinary tract injury are coexisting pelvic adhesion, distortion of normal pelvic configuration, previous irradiation history, previous operation history, and the extent of surgery. The second model presented is a prevalence-based dynamic model which links prevalence rates from one year to the next, and assesses effectiveness as the proportion of cases prevented.

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The influence of culture on the psychopathology of suicidal behaviour will be summed up systematically. After diagnosis of the histologically proven metastases, further palliative treatment was inadequate, except for radiotherapy to the brain. Increased muscle nucleoside levels associated with a novel frameshift mutation in the thymidine phosphorylase gene in a Spanish patient with MNGIE.

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We also mapped the mutation for two mutant lines to chromosomes 4 and 21, respectively. IRF-1 and IRF-2 expression was determined by real-time PCR in 138 ovarian cancer samples and 30 healthy ovarian biopsies and was correlated with the expression of other relevant immunologic parameters and common clinicopathologic variables. The influence of the increased MFN on the true digestibility of nitrogen and the amino acids was investigated in test series with casein diets. Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss.

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The regulation of GS activity involves two nucleotidylation cycles, the uridylylation cycle of PII and the adenylylation cycle of GS, which are catalyzed by two converter enzymes, uridylyltransferase and adenylyltransferase, respectively. In the light of these data and of animal model of HHT, the potential risk of developing other diseases in HHT patients will be discussed.

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SIMILAR AND DISSIMILAR MANIFESTATIONS OF OBSESSIVE-COMPULSIVE NEUROSES IN MONOZYGOTIC TWINS. These oncogenes act along the RET/PTC(TRK)-RAS-BRAF-MEK-MAPK kinase pathway, mediating a number of cellular fates including growth, proliferation and survival in thyroid cells. In National Health Interview Survey Disability Supplement Phase 2, people with personal care and household management disabilities were asked about fatigue, taking a long time, and pain when doing tasks on their own and with assistance.

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Pneumococcal vaccination: perceptions of primary care physicians. To examine the measurement properties of the French-Canadian version of the Life-Space Assessment questionnaire (LSA-F) for power mobility device (PMD) users. Tissue Doppler Tei index does not seem to be a suitable substitute for flow Doppler Tei index.

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Similarity and dissimilarity relationships between polynucleotide strings are measured in both spaces to compare their performance. Kallikreins isolated from rat pancreas, kidney, submandibular gland, brain, spleen and urine were indistinguishable with respect to molecular weight and immunological characteristics. The amount of in vitro BIOS produced with the diffusion-chamber method was greater than those produced previously with other culture methods, such as gel-stabilized gradient and batch liquid culture methods.

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Recovery of stroke hemiplegia through neurosurgical intervention in the chronic stage. These mentioned confirm the validity and reliability of this model. The results of an examination of 15 healthy individuals were taken as normal values.

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This type is termed Eimeria gerbilli after the generic name of its host. OMT-PLGA-MS was prepared with PLGA as carriers using double emulsion solvent evaporation method (W/O/W). In this study, we demonstrate that a soluble form of CIRL also exists in vitro and in vivo. Disruption of this gene has demonstrated that is an essential gene for yeast growth.

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Human nature and the nature of reality: conceptual challenges from consciousness research. Although functional biomechanical findings are more accurate predictors of injury and diagnostic tools than static findings, a correlation between the two is essential. Ganglion cell complex thickness, RNFL thickness and GCC mean superior and inferior hemispheric difference were compared between NAION and ON patients at each time-point using unpaired t-tests and between disease and control subjects at first measurement using paired t-tests.

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ISO/IEEE 11073 (X73) is a standard attempting to unify the interfaces of all medical devices. Bronchospasm, which is frequently associated with bronchial asthma, can present simultaneously with mucus transport abnormalities.

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Forensic DNA technology has recently been used to estimate the PMI. Of particular interest to our laboratory are transplantation strategies that focus on the induction of donor-specific T-cell unresponsiveness. Insect developmental inhibitors: a practical evaluation as mosquito control agents. Embryonic development is coordinated by sets of cis-regulatory elements that are collectively responsible for the precise spatio-temporal organization of regulatory gene networks.

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When accidentally severed, it may cause a bile leak leading to biloma formation. Baicalein is the most abundant component that has anti-HIV, anti-tumor, anti-oxidant and free radical scavenging functions. At his second presentation carotid angiography gave normal results, but a high resolution CT scan showed a tumour in the right parasellar region.

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PRED-CLASS: cascading neural networks for generalized protein classification and genome-wide applications. While exposure to neuroleptic drugs in the past was important, high rates of movement disorder were associated with the severe, untreated illness. The ts41 mutation of Chinese hamster cells was first isolated and characterized by Hirschberg and Marcus (1982) who showed that at nonpermissive temperature, cells accumulate up to 16C equivalents of DNA. Wire strains were calculated for each wire and compared within constructs and between ALT and SIM groups. In many cases it has been recognized that some characteristic chemical constituents could represent the therapeutical actions of the drugs.

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The aim of the present study was to investigate the effect of hyperoxia on caspase-3 and p53 gene expression and apoptosis in the lungs of neonatal rats, so as to determine the type of cell death that occurs in the lungs of neonatal rats exposed to hyperoxia. The effect of proteoglycans, collagen and lysyl oxidase on the metabolism of low density lipoprotein by macrophages.

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In a double-blind trial of 3 months 24 hypotensive patients suffering from migraine were treated with etilefrine pivalate (K 30 052, Ep, 20 mg p.o.) or dihydroergotamine (DHE, 5 mg) or placebo. Conversely, DHT treatment of hepatocytes from female fish significantly increased both the 25 and 30 kDa IGFBPs. Based on the increased consumption of alcohol in Denmark the aim of this study was to measure prevalence of abnormal liver-derived enzymes in a homogeneous Danish population and possible associations with alcohol consumption, smoking and body mass index (BMI).

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Pirenzepamine and gallamine did not affect carbachol action on LNCaP cells but diphenylpyralamine, an M3 receptor antagonist, completely blocked carbachol-induced DNA synthesis. Hemodynamic responses to captopril and d(CH2)5DAVP (in Long-Evans rats) in the presence of adrenoceptor antagonists were consistent with a major cardiovascular role of the renin-angiotensin system and a less overt role of vasopressin until the latter system was blocked. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. Dicyano compound 5 displays IC(50) values that are comparable to 2b against purified leishmanial tubulin assembly (6.6 vs 7.4 microM), Trypanosoma brucei brucei growth in vitro (0.26 vs 0.18 microM), Leishmania donovani axenic amastigote growth in vitro (4.4 vs 2.3 microM), and in vitro toxicity against Vero cells (16 vs 9.7 microM). The severity of the lesions was related to the duration of exposure more than to the concentration of the herbicide.

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The results have shown that all bases in the double helix are anti-orientated with respect to deoxyribose residues and that the sugar-phosphate backbone has an alternating architecture. To investigate the link between radiosensitivity and telomere length in murine lymphoid cell line stocks that have similar genetic backgrounds but different radiosensitivities. In this study, we evaluated the utility of the EBV-DNA load in CSF in identifying CNS involvement in patients with systemic ARL.

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Bone formation, estimated by 24-h whole body retention of diphosphonate (WBR), osteocalcin, alkaline phosphatase and calcium metabolic indices, was recorded before the start of medication and after 1 and 6 months of treatment. The specificity and activity of p24 protein were tested by WB and ELISA. We now demonstrate that treatment of K562 cells with taxol leads to sustained activation of PKCiota.

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Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles. Rapid characterization of mutations in amplified human hprt cDNA by polyacrylamide gel electrophoresis. Acetic acid extracts from non-synchronized infected cultures were shown by radioimmunoassay to contain the equivalent of 150 molecules of somatostatin per parasite. The major cellular response to LPS, reflected in BAL fluid, was an approximately hundredfold increase in neutrophils. Quantification and distribution of cerebral emboli during cardiopulmonary bypass in the swine: the impact of PaCO2.

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STUDIES ON THE COULOMETRIC DETERMINATION OF CAFFEINE, THEOBROMINE AND THEOPHYLLINE. Immunogold particles were consistently found in the dense-core granules of mice and nude mice at all antisera dilutions, but not in the other species, except in the dog, where a very low labelling response was encountered. Production of beta-lactamase could then be induced by a shift in temperature and without concomitant cell lysis, facilitating purification of the protein from the culture supernatant. The ensuing controversy surrounding research on the outcome of MHI and the postconcussion syndrome reflects ambiguities in definition, inconsistencies in criteria for patient selection, variation in procedures for neurobehavioral assessment, and difficulty in obtaining follow-up data. We present an in vitro model to test the direct influence of vitamin supplementation on corneal endothelial cells with regard to lipid peroxidation and apoptosis.

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The association pattern of acrocentric chromosomes in patients with trisomy 13. Developmental analysis of factors binding to the mouse 68-kDa neurofilament promoter. First report: the change of the E-PTFE graft and bladder wall after partial replacement of the bladder wall

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The International Year of the Child: W.H.O.--U.N.I.C.E.F.--I.S.R.R.T.--and you. Our data demonstrate that cones utilize specific parallel excitatory and inhibitory circuits to modulate DAC activity and efficiently regulate dopamine release and the light-adaptive state of the retina. Numerous L-ENK-immunoreactive cell bodies, and moderate numbers of CCK-, NT-, and CRF-stained cell bodies were found in the AVPv.

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Upon resumption of erythropoiesis the release of freshly prepared erythrocytes containing MTX and predominantly MTX polyglutamates causes the renewed increase in blood MTX levels. Characterization of obesity phenotypes in Psammomys obesus (Israeli sand rats).

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Type III restriction enzymes communicate in 1D without looping between their target sites. Finally, silencing of RAMP1 in the endogenously expressing HEK293 cells using siRNA resulted in altered CaSR traffic. Experimental destructive lesions were produced at autopsy in the lumbar discs of nine spines including 29 radiologically normal adult lumbar intervertebral discs. A linear mixed-effects model was fit to compare outcomes between the two treatment groups and to model trends over time.

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The capacity to inhibit CCR2 expression in monocytes was shared by other microbial agents and cytokines (inactivated Streptococci, Propionibacterium acnes, and to a lesser extent, IL-1 and TNF-alpha). We have taken advantage of the sensitivity of the CH(3)-H(4)PteGlu(3) absorption spectrum to probe its protonation state when bound to MetE.

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The possible adaptative value of these differences is pointed out. Less is known about the sources of illness perceptions, in particular the role of environmental factors such as primary care supply.

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The possible existence of breed differences in the response of sheep to primary infection with Haemonchus contortus was examined by comparing worm establishment and pathogenic effects of the parasite in Awassi and Merino sheep of haemoglobin type B infected with 500 third stage H. The time course of the reaction has been measured at several wavelengths and has been found to be biphasic.

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The self-diffusion coefficient of water (D) inside bioadhesive bonds formed by dry and prehydrated hydrophilic matrices has been spatially resolved using nuclear magnetic resonance (NMR) microscopy. However, the laminar input to the 2 populations of tall pyramidal cells was indistinguishable. Longer follow-up periods will be required to establish whether or not the durability of symptom relief after lesioning an elongated segment of the trigeminal root is superior to isocentric radiosurgical rhizotomy.

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The homogeneous enzyme contains riboflavin (0.5 mol/112 kDa), iron and sulfur (3.5 mol/112 kDa each). These variations in the branches of the cervical plexus should be known to the anaestheticists while they give anaesthesia to a particular nerve during a nerve block. Media stories, publicity, or social discourse about the reported health effects of wind turbines are likely to trigger reports of similar symptoms, regardless of exposure. The ability of magnetic resonance imaging (MRI) to display the anatomic changes after spinal cord injury in the rat were examined in postmortem specimens.

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Direct vision intracardiac surgical correction of congenital heart defects. Considerations on specialists and insurance policies for the improvement of maxillofacial prosthetics in Korea are required. A 24-year-old female suffered from acute pancreatitis, followed by simultaneous onset of painless goiter, elevation of thyroid hormones and diabetic ketoacidosis. Rare fragile sites are seen in a small proportion of individuals and are inherited in a Mendelian manner.

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To determine the degree of switching from non-selective NSAIDs to COX-2 inhibitors and to examine the factors that were associated with switching. Herein we describe the development, characterization and application of an electrochemical sensor based on the use of Nafion/MWCNT-modified screen-printed carbon electrodes (SPCEs) for the voltammetric detection of the anti-tuberculosis (anti-TB) drug ethambutol (ETB).

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THE ACTIVITIES OF AN EMERGENCY RELIEF GROUP DURING THE NIIGATA EARTHQUAKE This study shows that vancomycin use in our hospital resulted in a lower selection pressure than has been reported for US university-affiliated hospitals and that comprehensive programs to improve use of vancomycin are needed in our institution.

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Converting a knee supporter into a effective shoulder support device. Other questions are of special medical importance and relevant reports are reviewed along with a description of current efforts to provide answers. Furthermore, overexpressed NFR1 or NFR5 associated with endogenous SYMRK in roots of the legume Lotus japonicus. In view of the adverse effect of postoperative adhesions on the result of infertility surgery, we suggest that the use of intraperitoneal heparin in the human should receive serious consideration.

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Because he got worse, however, he was treated with another combination chemotherapy, consisting of Methotrexate (MTX, 100 mg/m2 intravenous push (i.v.), 200 mg/m2 12-h infusion, day 1. Social identity salience shapes group-based emotions through group-based appraisals. When the tumor enzyme was treated with exogenous sialidase, alkaline phosphatase, or endo-beta-N-acetylhexosaminidase H (endoglycosidase H), the acidic components of the enzyme shifted to the more alkaline region on the focussing gel. This case reminds us of the importance of considering the possibility of this condition whenever a patient with chronic pancreatic disease develops sterile osteoarthritis. Molecular cloning of a putative cyclic nucleotide-gated ion channel cDNA from Limulus polyphemus.