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Rhinolast (Azelastine)

Rhinolast is an intranasal antihistamine indicated for use in patients with seasonal allergic rhinitis (SAR) and non-allergic vasomotor rhinitis (VMR). A side effect of this medication is bitter taste which many patients find aversive. To address the issue of bitter taste, Rhinolast has been reformulated to include sucralose and sorbitol. The new formulation (Astepro 0.1%) is approved for seasonal and perennial allergic rhinitis and has been demonstrated to have comparable pharmacokinetics, pharmacodynamics and therapeutic efficacy compared to Rhinolast. More recently, Astepro at a concentration 0.15% has been approved for once a day use. This review will provide an overview of the old and new formulations of Rhinolast.

Other names for this medication:
Azelastine, Afluon, Allergodil, Astelin, Astepro, Asthafen, Azel, Azelastin, Azelastina, Azelone, Azen, Azep, Azeptin, Ketasma, Lastin, Optilast, Optivar, Otrivine, Phenergan, Rhinolast, Rinalin, Xanaes,

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The interdependence of the three areas of patient improvement assessments used in a comparative study has been studied. Construction of a physical map of an autism susceptibility region in 7q32.3-q33.

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The correlations were reduced or reversed at depth, however, suggesting a dissociation of E-C coupling. There was a significant diet x day interaction for the proliferative response of mononuclear cells after calving and AI, indicating that cell responses from cows fed flaxseed were transiently reduced compared with those fed Megalac and soybeans. Geographical factors have an impact on the utilisation of out-of-hours services. After administration of HA-1077 eye drops, there was a significant time- and dose-dependent decrease of the IOP.

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Protein kinase B (Akt) gene regulated osteopontin expression in RNA level and protein level, suggesting that osteopontin synthesis can be blocked by inactivation of the Akt gene. The signal transduction pathways associated with TH-mediated maturation of astrocytes have been investigated.

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Acute irradiation effects on morphology and function of rat submandibular glands. Interaction of different ocular endotamponades as a risk factor for silicone oil emulsification. The Morris water maze, developed by Morris (J Neurosci Methods 1984: 11: 47-60), is a behavioral experiment designed to test the spatial memory. Collectively, these results suggest that SCIO-469 treatment can suppress factors in the bone marrow microenvironment to inhibit MM cell proliferation and adhesion and also to alleviate osteolytic activation in MM. Evaluation of the clinical features and epidemiology of textile contact dermatitis (TCD) in Italy.

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Successful treatment of high congenital dislocated hips in older children by open reduction, pelvic and femoral osteotomy with external fixator stabilization (average 8.2 years of age). A low incidence of infection in abdominal wounds after contaminated, infected, and selected clean-contaminated operations was achieved after delayed wound closure of the skin and subcutaneous tissue. Crystal structures of cleaved and uncleaved forms of the YscU cytoplasmic domain, an essential component of the type III secretion system (T3SS) in Yersinia pestis, have been solved by single-wavelength anomolous dispersion and refined with X-ray diffraction data extending up to atomic resolution (1.13 A).

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