Sildenafil is one of the best-known treatments for erectile dysfunction (ED). ED is caused by insufficient blood flow to the penis, resulting in the inability to maintain an erection. Sildenafil can dramatically enhance the quality of an erection by increasing blood flow to the penis. Its effect lasts for 4-6 hours. Sildenafil is widely known to treat PAH (pulmonary arterial hypertension). Sildenafil is an anti-impotence drug which enables men to achieve and sustain an erection. The active ingredient of Sildenafil is PDE-5 inhibitor. In response to sexual arousal, Sildenafil stimulates the release of nitric oxide (NO) in the corpus cavernosum. Nitric oxide activates the lyase enzyme which is followed by increasing levels of cyclic guanosine monophosphate (cGMP). This cyclic nucleotide relaxes smooth muscles in blood vessels of the corpus cavernosum, increasing blood flow and thus inducing an erection. Along with the treatment of erectile disorders, Sildenafil effectively prolongs sexual performance, preventing premature ejaculation (PE). Sildenafil is also used in the treatment of PAH (pulmonary arterial hypertension).
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