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Hyperactivity of central neuropeptidergic circuits such as the corticotropin-releasing hormone (CRH) and vasopressin (AVP) neuronal systems is thought to play a causal role in the etiology and symptomatology of anxiety disorders. We propose that the centrosomal phosphorylation of D-TACC on Ser863 allows D-TACC-Msps complexes to stabilize the minus ends of centrosome-associated MTs. The effect of cytidine and uridine on the reparative processes in the rat liver in experimental hepatitis induced by CCl was studied. Interestingly, we found that all the DP molecules recognized by the alloantibodies displayed the same amino-acid sequence suggesting that epitope sharing between unrelated HLA molecules was the mechanism underlying NDSA generation.

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The aim was to investigate elastic wall properties of the isolated perfused porcine duodenum using manometry and impedance planimetry. Thirty preretinal membranes excised from diabetic patients during pars plana vitrectomy were examined by transmission electron microscopy, scanning electron microscopy, or both.

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The onset of pulmonary hypertension in patients with systemic sclerosis carries a poor prognosis. One-pot enantioselective aziridination of olefins catalyzed by a copper(I) complex of a novel diimine ligand by using PhI(OAc)(2) and sulfonamide as nitrene precursors. The fully absorbed antiserum and the murine MAbs both identify a polypeptide pattern possibly related to human glial fibrillary acidic protein (GFAP) or other intermediate filament proteins on immunoblots. Whereas some mutants exhibit an almost normal deposition pattern, some show complete lack of deposition. Soft hydrogels from nanotubes of poly(ethylene oxide)-tetraphenylalanine conjugates prepared by click chemistry.

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On the basis of some of this information, two oligonucleotide mixtures, 17 and 18 bases in length, have been synthesized and used as hybridization probes in the isolation of clones of the cognate cDNAs. An MDM2 deletion mutant (MDM2(Delta222-437)) with activated cryptic nucleolar localization signal also targets p53 to the nucleolus and efficiently promotes p53 sumoylation in the absence of ARF. Use of the in vitro cumulative gas production technique for pigs: an examination of alterations in fermentation products and substrate losses at various time points. Ventricular septal defect and mitral regurgitation complicating acute myocardial infarction.

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The sole inclusion criteria were the diagnosis of WHO-AML and treatment with at least one dose of azacitidine. Intubated ureterotomy: report of animal experimentation and clinical cases. Therefore, these dose ranges and up-dosing regimens can be safely included in future dose-finding efficacy studies.

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Indications and adverse effects of corticosteroid therapy in dermatology Pilin independent binding of Neisseria gonorrhoeae to immobilized glycolipids.

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Noncoding RNAs (ncRNAs), including microRNAs, are a novel class of regulatory molecules that control the gene expression in a posttranscriptional manner. Mechanisms of biocontrol by Pantoea dispersa of sugar cane leaf scald disease caused by Xanthomonas albilineans. These results suggest that American bats may not be reservoirs or amplification host for DENV infection.

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The association of ED (erectile dysfunction) with ED (endothelial dysfunction) in the International Journal of Impotence Research: The Journal of Sexual Medicine. This article reviews current cell-free protein array technologies and their proteomic applications.

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Activin has complex effects on cell growth during branching morphogenesis, but it is generally considered as an inhibitor of cell proliferation as in vitro studies have shown that activin A treatment of breast cancer cells arrests cell growth. Poly(2-ethyloxazoline) as matrix for highly active electrospun enzymes in organic solvents.

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The ACh response was reversibly blocked by 10(-6)M-tubocurarine and irreversibly blocked by 10(-6)M-alpha-bungarotoxin. Immunologic responses in normal tissues, local stromal microenvironment, and specific antigen-presenting cells induced by such high doses likely contribute to effective tumor kill.

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Two reviewers independently extracted data, assessed trial quality and resolved discrepancies together with a third party. Self-assembling systems based on amphiphilic poly-N-vinylpyrrolidone and their interaction with model proteins.

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Molecular remission occurring after donor leukocyte infusions for the treatment of relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation. The management of patients with unknown primary carcinoma (UPC) has evolved over the last few years and the recently developed sophisticated diagnostic modalities and novel therapies present both an opportunity for and a challenge to treatment of patients with this heterogeneous group of neoplasms. The effects of the frequency and the interrogation parameters on sample identification performance were investigated.

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India has one of the highest tuberculosis (TB) burdens globally. Raman spectroscopy is a specialized technique that permits highly specific identification of specimens, in contrast to fluorescence spectroscopy with which analysis of arterial tissues generates spectra that are broad and featureless, with little difference seen between normal artery and atheroma. Our goal was to identify what eating disorder clinicians do with their patients in a more theoretically neutral context.

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STUDIES ON THE ROLE OF ANTIFIBRINOLYSIS IN THE PATHOGENESIS OF ARTERIOSCLEROSIS Suppression of phosphatidylinositol-3-kinase (PI3K)/Akt pathway by LY294002 restored chemosensitivity of Smad4-deficient cells to 5-FU.

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We carried out an association study in which 463 single nucleotide polymorphisms (SNPs) in 33 candidate genes were genotyped in 75 Japanese patients who had received IFN-alpha for MRCC. In focus groups, 1st- and 4th-year college women were presented with a series of three vignettes depicting incidents that meet the legal criteria for rape yet are ambiguous due to the presence of cultural rape myths, contexts involving alcohol consumption, varying degrees of consent, and a known perpetrator. Cardiac function was evaluated using 1 hour of low-flow ischaemic stress followed by 30 minutes of reperfusion. Desmoid tumors of the pediatric mandible: case report and review. This pilot study demonstrates the feasibility of PTD for aiding PFMT.

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A sensitivity analysis was conducted to gauge the effects of uncertainty in the values assigned to variables. The study population comprised 23 patients aged 2.6 to 12.5 years with symptoms of obstructive sleep apnea, hypertrophic tonsils with no other areas of upper airway obstruction with the exception of hypertrophic adenoids, and a body mass index (calculated as weight in kilograms divided by the square of height in meters) of less than 30. Strategies and best practices for building community capacity in evaluation research are provided, and theoretical considerations for conducting community-based health interventions are raised.

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Biofilm pneumococci are predominately in the transparent phenotype, which has elevated cell wall phosphorylcholine, an adhesin subject to C-reactive protein mediated opsonization. Opposing effects of cyclosporin A and anti-interferon-gamma antibodies on immune tolerance mechanisms.

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Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells. It is unknown what are the neurologic neutral zones of the spine within which reflexive EMG does not exist, as well as the dependence of such neurologic neutral zones on viscoelastic hysteresis and increasing frequency of a flexion-extension cycle.

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Examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated HFRS indicate that these viruses represent a new and unique group that constitutes a separate genus in the Bunyaviridae family of animal viruses. The combination of ciprofibrate and PGF2alpha blocked the inhibitory effect of transforming growth factor (TGF)-beta on the DNA binding activity of AP-1 induced by EGF. This process is highly effective at removing the hysteresis in the channel conductance, and time-dependent measurements further demonstrate that the drain current is stable and single-valued, independent of the prior measurement history. The management of symptomatic patient ductus arteriosus in premature infants.

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The DNA-binding activities of induced and uninduced MEL cell nuclear extracts were decreased by incubation with phosphatase, showing that phosphoryl-ation and DNA binding of GATA-1 are already optimalin these cells. Addition of cholesterol to the MUFA diet decreased CETP activity, whereas addition of cholesterol to the SFA diet had no effect. Prevalence of self-reported illnesses in elderly Hispanic and non-Hispanic Whites in New Mexico. Responses to Questions 3 and 4 were compared with mid-pregnancy serum cotinine levels.

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MR imaging of patients with localisation-related seizures: initial experience at 3.0T and relevance to the NICE guidelines. In addition, they may associate with malignant transformation of host cells and are also considered to be cofactors in the progression of AIDS. Smoking and reproduction: the oviduct as a target of cigarette smoke. The treatment of psychiatric disorders in patients with chronic airways obstruction.

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Glucagon rapidly inactivates acetyl-CoA carboxylase with an accompanying 4-fold increase in the phosphorylation of the enzyme and 3-fold increase in the protomer-polymer ratio of enzyme protein. The clinical diagnosis of drug abuse is frequently omitted from the differential diagnosis of transient fevers, arrhythmias and changes in mental status in the elderly despite the high risk of iatrogenic dependence in this age group. Under our protocol, capture performance and precision of calling were compatible to conventional MIP capture methods, yet overlapping targets and unique barcodes allowed us to precisely genotype with as little as 50 ng of input genomic DNA without library preparation.

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N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin. In addition, genetic alterations of the histone chaperones that specifically regulate chromatin incorporation of histone variants are rapidly being uncovered in numerous cancers.

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Invasive techniques for the diagnosis of respiratory infections. Statistical analysis was performed using the Wilcoxon signed rank test. On the basis of the data of this report a detailed illustration of the events that follow the T cell activation is presented. In support of this, in the last two decades, clinical and preclinical research provided evidence of correlations and to some degree causal links, between aberrant ECM function and neuropsychiatric disorders, the most prominent being addiction and schizophrenia. All diagnostic categories are explored in detail, and comparisons are made among urban, rural, and residency practices.

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Pesticide removal from container nursery runoff in constructed wetland cells. The impact of the introduction of a palliative Macmillan consultant radiographer at one UK cancer centre. Enzymatic hydrolysis of cellulose is one of the bottlenecks in the commercialization of the process due to low hydrolysis rates and high cost of enzymes. hoyamushi density during the development of STS in the tunics of ascidians (Halocynthia roretzi) using real-time polymerase chain reaction (qPCR).

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Phosphorous pentachloride chemical burn--a slowly healing injury. Market opportunities and technology trends in point of care diagnostics - SMi conference. High levels of substance P-like immunoreactivity were demonstrated by radioimmunoassay in the plasma and tumour of a patient with a medullary carcinoma of the thyroid. 81 benefit-eligible patients and 23 community pharmacy coaches employed by the self-insured pharmacy chain. Bone microstructure parameters obtained with HRpQCT are associated with prevalent fracture in men and women.

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Carbohydrate antigens on the surface of mammalian cells have recently gained renewed interest because some are specifically expressed at certain stages of cellular differentiation. A case of basilar impression associated with Arnold-Chiari malformation and with trigeminal neuralgia is reported. Determination of trace amounts of sulphide in human red blood cells by high-performance liquid chromatography with fluorimetric detection after derivatization with p-phenylenediamine and iron(III). Surgical decompression of patients with large middle cerebral artery infarcts is effective: not proven. Long-term maintenance of neurologic function in shunt-dependent individuals requires vigilance and attention to detail.

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All patients with AF persisting for more than 24 to 48 hours and without contraindication should receive anticoagulation. Approximation-Based Adaptive Tracking Control for MIMO Nonlinear Systems With Input Saturation. Effect of frameless stereotaxy on the accuracy of C1-2 transarticular screw placement. A comparative psychophysical approach to visual perception in primates. In this update, users are allowed to search a group of interested proteins/genes and the system reconstructs the SNO regulatory network based on the information of metabolic pathways and protein-protein interactions.

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Infrared Photodissociation Spectroscopy of C4 N- , C6 N- and C8 N. Emergence of multiplicative auditory responses in the midbrain of the barn owl.

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These negative results are not consistent with long-lasting hypofrontality, a major landmark of human schizophrenia, in the PCP rat model. An early prediction of ADMET (Absorption-Distribution-Metabolism-Excretion-Toxicity) properties is important during drug development, since interference of a compound with P-gp might compromise its future development into a drug. High density lipoprotein subfraction cholesterol in hypertriglyceridaemia. A three-amino-acid insertion in 1a that blocks BMV RNA replication in vivo also blocked in vitro interaction with 2a, while another two-amino-acid insertion that renders the 1a protein temperature sensitive for RNA replication interacted in vitro with 2a at 24 degrees C but not at 32 degrees C. The results confirmed the reliability and validity of the AIMS instrument.

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Comparative studies on pyrimidine metabolism in excised cotyledons of Pinus radiata during shoot formation in vitro. No evidence for involvement of plasma proteins or blood-borne cells in amyloid plaque formation in scrapie-affected mice. Waveform analysis could not be done by aliasing of the recording device in equipment D. The proposed assisted dying bill in the U.K.: a response to Lord Joffe.

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Expression of six expansin genes in relation to extension activity in developing strawberry fruit. Factors which may influence the effectiveness of L-asparaginases as tumor inhibitors. Microinjection of morphine into the LRN in conscious rats produced an antinociception in both TF and hot plate (HP) tests which could be attenuated significantly by naloxone, but not atropine, previously microinjected into the same site in the LRN. Hepatitis B virus enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity by increasing TRAIL-R1/death receptor 4 expression. The dosimetric impact of vaginal balloon-packing on intracavitary high-dose-rate brachytherapy for gynecological cancer.