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Xenalon (Spironolactone)

Xenalon is a potassium-sparing diuretic that removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease. It also can be used in combination with other drugs to treat diuretic-induced low potassium (hypokalemia) and high blood pressure. Xenalon also is used to counteract the effects of excessive adrenal aldosterone production (hyperaldosteronism) that can occur from a tumor in the adrenal gland or enlarged adrenal glands (hyperplasia of the adrenal glands). Xenalon and its active metabolites are specific pharmacologic antagonists of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Xenalon causes increased amounts of sodium and water to be excreted, while potassium is retained. Xenalon acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents that act more proximally in the renal tubule.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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Functional evidence suggests that the stimulation of peripheral and central opioid receptors (ORs) is able to modulate heart function. Serum levels and activity of indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase and their association with disease severity in patients with chronic kidney disease. Stereoselective syntheses and CNS activity of novel tricyclic amines.

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Occupancy of Nociceptin/Orphanin FQ Peptide Receptors by the Antagonist LY2940094 in Rats and Healthy Human Subjects. Within several days the lesion increased in size and was then falsely considered to be an intraventricular haemorrhage. Experienced nurses used the heuristic, Judging by Causal Systems (diagnostic inferences deduced from systems of causal factors) significantly more did than less-experienced nurses. A review of studies reported from 1966 to 1998 and identified through a MEDLINE search of the English-language literature on metabolic and toxic seizures and status epilepticus. Medical charts of the patients with discrepant laboratory findings were reviewed and compared with the United States Centers for Disease Control and Prevention (CDC) clinical case definition.

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This egocentric effect (traditionally called frustration) is correlated to activation of the hypothalamic-pituitary-adrenal axis, can be modulated by treatment with anxiolytics, and is expressed in terms of behavioral changes that have an emotional component (e.g., agonistic behavior). We measured baseline serum osteoprotegerin, bone metabolism markers, and bone mineral density in hemodialysis patients. Gene expression level influences amino acid usage, but not codon usage, in the tsetse fly endosymbiont Wigglesworthia.

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Most gynecologists in ART programs believe they have a duty to look out for the unborn child. We used an artificial neural network (ANN) computer model to study peptide binding to the human transporter associated with antigen processing (TAP). Anthrax, a potentially fatal infection, is a virulent and highly contagious disease. To observe the effects of the water-extraction of Astragali Radix and Lycopi Herba on the signaling pathway of TGF-Smads-UPP in streptozotocin (STZ)-induced DN.

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